I've always been partial to the Flint Hills ..... but I also enjoy the drive from Newton to Emporia on HWY 50, the stretch from Holton to Tonganoxie on 16, and I-70 west of Salina (just love farmland)..... nice view from Coronado Heights ..... have also enjoyed many of Kansas' man-made lakes ...... those are just off the top of my head ..... so I'd have to say that the best part of Kansas is wherever you happen to be.
Good question though!